Bisphosphonates as Superior Bone Imaging Agents
نویسندگان
چکیده
A series of novel zoledronic acid (ZL) derivatives 1-hydroxy-3-(2-methyl-1H-imidazol-1-yl)propane-1,1-diyldiphosphonic acid (MIPrDP), 1-hydroxy-4-(2-methyl-1H-imidazol-1-yl)butane-1,1-diyldiphosphonic acid (MIBDP), and 1-hydroxy-5-(2-methyl-1H-imidazol-1-yl)pentane-1,1-diyldiphosphonic acid (MIPeDP) were prepared and successfully labeled with Tc in high labeling yields. The in vitro stability and in vivo biodistribution of Tc-MIPrDP, Tc-MIBDP and Tc-MIPeDP were investigated and compared. The biodistribution studies indicate that the radiotracer Tc-MIPrDP has highly selective uptake in the skeletal system and rapid clearance from soft tissues. The present findings indicate that Tc-MIPrDP holds great potential for use in bone imaging.
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